Involvement of T 6 pili in biofilm formation by serotype M 6 Streptococcus 1 pyogenes

Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus 1 pyogenes 2 3 4 Keiji Richard Kimura , Masanobu Nakata , Tomoko Sumitomo, Bernd Kreikemeyer, 5 Andreas Podbielski, Yutaka Terao, and Shigetada Kawabata* 6 7 8 Department of Oral and Molecular Microbiology, Osaka University Graduate School of 9 Dentistry, 1-8, Yamadaoka, Suita, Osaka, 565-0871, Japan. 10 Institute of Medical Microbiology, Virology and Hygiene, University of Rostock, D-18057, 11 Rostock, Germany. 12 These authors contributed equally to this work. 13 14 15 *To whom correspondence should be addressed: Department of Oral and Molecular 16 Microbiology, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, Suita, 17 Osaka, 565-0871, Japan. Tel.: (+81) 6 6879 2896; Fax: (+81) 6 6879 2180; E-mail: 18 [email protected]. 19 20 21 Running title: T6 pili promote biofilm formation 22